Geed Lab

Neuroplasticity and Motor Function Recovery after Stroke

Neurophysiology of critical period neuroplasticity


Individuals with stroke are "preferentially responsive" to arm rehabilitation if therapy is provided within an early critical period window of stroke.

The post-stroke critical period lasts up to three months, likely a little longer than that post stroke. The preferred responsiveness seems to spontaneously disappear by around 6-months after stroke.

What makes the neuronal circuitry particularly responsive to behavioral experience (therapy) early post stroke?

Similar time-sensitive windows of preferred responsiveness to behavioral experience, called critical periods, occur in the developing nervous system. These critical period windows are governed by distinct genetic-molecular cascades, and result in characteristic neurophysiological changes indicative of heightened neuroplasticity. This project is testing if similar neurophysiological mechanisms occur in post-stroke critical periods as during juvenile critical periods. 

Publications


The Critical Period after Stroke Study (CPASS) Upper Extremity Treatment Protocol


Jessica Barth, Shashwati Geed, Abigail Mitchell, Kathaleen P. Brady, Margot L. Giannetti, A. Dromerick, D. Edwards

Archives of Rehabilitation Research and Clinical Translation, 2023


Critical Period After Stroke Study (CPASS): A phase II clinical trial testing an optimal time for motor recovery after stroke in humans


A. Dromerick, Shashwati Geed, Jessica Barth, Kathaleen P. Brady, Margot L. Giannetti, Abigail Mitchell, M. Edwardson, Ming T. Tan, Yizhao Zhou, E. Newport, D. Edwards

Proceedings of the National Academy of Sciences, 2021


Interpreting the CPASS Trial: Do Not Shift Motor Therapy to the Subacute Phase


M. Edwardson, Kathaleen P. Brady, Margot L. Giannetti, Shashwati Geed, Jessica Barth, Abigail Mitchell, Ming T. Tan, Yizhao Zhou, B. Bregman, E. Newport, D. Edwards, A. Dromerick

Neurorehabilitation and Neural Repair, 2022

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